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Monday, November 24, 2025
It’s not all in her head — mystifying and sometimes even debilitating, headache disorders are the second most common condition worldwide. Young and middle-aged women carry a disproportionate burden of headache disorders, according to a recent study in Cell Reports Medicine, which dives headfirst into the demographics of headache disorders.
Although previous studies have suggested that women experience headache disorders more often, the corresponding author, immunologist Professor Dong Keon Yon of Kyung Hee University, says, “We were still struck by just how consistent and substantial the disparity remained across regions and over three decades of data,”.
Women in countries with more access to healthcare were found to face the highest prevalence and disability rate. In regions with less accessible health care, headache disorders are underdiagnosed and, as a result, underreported. Yon says that the study’s forecast that the disability burden in young and middle-aged women with migraines will remain stable to 2050 highlights the importance of healthcare access and effective treatments.
- Tissa Wijeratne, Jiyeon Oh, Soeun Kim, Yesol Yim, Min Seo Kim, Jae Il Shin, Yun-Seo Oh, Raon Jung, Yun Seo Kim, Lee Smith, Hasan Aalruz, Rami Abd-Rabu, Deldar Morad Abdulah, Richard Gyan Aboagye, Meysam Abolmaali, Dariush Abtahi, Ahmed Abualhasan, Rufus Adesoji Adedoyin, Qorinah Estiningtyas Sakilah Adnani, Fatemeh Afrashteh, Navidha Aggarwal, Danish Ahmad, Ali Ahmadi, Negar Sadat Ahmadi, Amir Mahmoud Ahmadzade, Syed Anees Ahmed, Salah Al Awaidy, Sawsan Alabbad, Muaaz M. Alajlani, Yazan Al-Ajlou. Global, regional, and national burden of headache disorders, 1990–2021, with forecasts to 2050: A Global Burden of Disease study 2021 — Cell Reports Medicine, October 21, 2025
- Lars Jacob Stovner, Emma Nichols, Timothy J. Steiner, Foad Abd-Allah, Ahmed Abdelalim, Rajaa M. Al-Raddadi, Mustafa Geleto Ansha, Aleksandra Barac, Isabela M. Bensenor, Linh Phuong Doan, Dumessa Edessa, Matthias Endres, Kyle J. Foreman, Fortune Gbetoho Gankpe, Gururaj Gopalkrishna, Alessandra C. Goulart, Rahul Gupta, Graeme J. Hankey, Simon I. Hay, Mohamed I. Hegazy, Esayas Haregot Hilawe, Amir Kasaeian, Dessalegn H. Kassa, Ibrahim Khalil, Young-Ho Khang, Jagdish Khubchandan, Yun Jin Kim, Yoshih. Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 — The Lancet Neurology, November 1, 2018
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